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Centralized drug procurement is an important measure to alleviate the high cost of drugs for the masses. However, due to the difficulties in platform interaction, low transparency, privacy disclosure and other problems of centralized drug procurement, the efficiency of drug circulation is low and violations emerge in an endless stream. Blockchain technology is characterized by decentralization, tamper-proof, autonomy, etc. Combined with the features of numerous participants in centralized drug procurement and large amount of data processing, a framework for centralized drug procurement based on super ledger is built, and identity registration chain code, price negotiation chain code, and contract performance chain code are designed to realize centralized drug procurement autonomy, openness, transparency, and traceability. It aims to improve centralized drug procurement and ensure transparency and accountability throughout the drug supply chain in order to maximize the effect of lower prices brought about by healthcare reform.