Occupational, accidental, diagnostic, or therapeutic exposure to ionizing radiation (IR) in today's world is inevitable. Radiation, a known mutagen, can also impart transgenerational effects and lead to life-threatening diseases like cancer, cardiovascular, diabetes, or neurological disorders. Recently, epigenetic effects of radiation exposure are being elaborately studied worldwide. DNA methylation and histone modifications (acetylation, methylation, phosphorylation, and sumoylation)-led chromatin remodeling and subsequent alterations in gene expression pattern are being studied more explicitly in various pathophysiological or stress conditions. Epidrugs can modulate the epigenetic aberrations caused

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