Aquaculture is gaining commendable importance to meet the required protein source for ever increasing human population. The aquaculture industry is currently facing problems on developing economically viable production systems by reducing the impact on environment. Sustainable and enhanced f ish production from aquaculture may be better achieved through application of recent biotechnological innovations. Utilisation of transgenic technology has led to production of f ishes with faster growth rate with disease resistance. The full advantage of this technology could not be achieved due to concern of acceptance for Genetically Modif ied Organisms (GMOs). The biotechnological intervention in developing plant based feed ingredient in place of f ish meal which contain high phosphorus is of prime area of attention for f ish feed industry. The replacement of f ish meal will also reduce f ish feed cost to a greater extent. Year round f ish seed production of carps through various biotechnological interventions is also need of the hour. This paper discusses technical, environmental and managerial considerations regarding the use of these biotechnological tools in aquaculture along with the advantages of research application and its commercialization.