Introduction:Tissue conditioners are used to improve the health of the soft tissues of denture-bearing areas. However, leaching of plasticizers from tissue conditioners results in deterioration, which necessitates frequent replacement. The life of these liners varies, but it can be extended by the use of a coating material.Aim:To evaluate the surface roughness of a tissue conditioner with monopoly coating, subjected to denture cleanser and disinfectant.Materials and Methods:Sixty disk-shaped specimens of Visco-gel were made and divided into six groups of 10 each (control 1 [C1], control 2 [C2], control 3 [C3], group 1 [M1], group 2 [M2], and group 3 [M3]). Specimens of the control group were not coated with monopoly, while the specimens of the groups 1, 2, and 3 were coated with monopoly. Specimens of C1 and M1 were immersed in distilled water. Specimens of C2, C3, M2, and M3 were immersed into solution of denture cleanser for 8 h at room temperature and immersed in distilled water for the remainder of the 24-h period. C3 and M3 specimens were treated with disinfectant for 10 min before testing the surface roughness. The surface roughness was measured on 1st, 3rd, 5th, 7th, and 14th day, using a contact profilometer. Student's paired t-test was used to compare the mean Ra values within each group. In the present study, P < 0.05 was considered as the level of significance.Results:The mean surface roughness values of M1, M2, and M3 groups were less than C1, C2, and C3, respectively. Among all the groups, M1 showed the least surface roughness values.Conclusion:Monopoly-coating agent prevents the deterioration and reduces the surface roughness of the tissue conditioner.