BACKGROUND Henoch-Schonlein Purpura (HSP) is a systemic small vessel vasculitis with multiorgan involvement characterised by palpable purpura, arthritis, abdominal pain and renal disease. The aetiology and clinical features are varied but histopathology is characterised by leucocytoclasia with deposition of IgA immune complexes. Aims and Objectives-The present study was done to know the spectrum of various cutaneous manifestations, systemic involvement and aetiology of Henoch-Schonlein purpura.

Dariers disease (Keratosis follicularis) is an autosomal dominantly inherited, acantholytic disorder due to mutation in ATP2A2 gene located on chromosome 12. Darriers disease can be localised to a segment due to postzygotic mutations where it is called as segmental darriers. Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar pits and papules on the dorsum of the hands and feet. There is increased predisposition to non-melanoma cutaneous malignancies in darriers disease. We report a rare case of darriers disease with basal cell carcinoma A, with rapid progression over 4 months into ulcus penetrans with destruction of eye ball.

BACKGROUND:Lichen planus is a chronic inflammatory disease that effects skin, mucous membranes, hair and nails. There are several drugs both topical and systemic for the treatment of lichen planus. AIMS AND OBJECTIVES: Present study was done to compare the efficacy between oral mini pulse therapy with betamethasone and with acetretin in the management of generalised lichen planus. MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen planus, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Vishakhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups. Group1 patients were treated with 0.1mg/kg of oral betamethasone given on 2 consecutive days in a week till 8 weeks and tapered. Group 2 patients were treated with 0.5mg/kg of acetretin for 8 weeks and tapered. INCLUSION CRITERIA: All patients of age group in between 11-60 years, of either sex, suffering from lichen planus of duration >3 months, and women in group 2 who were in reproductive age group on two methods of contraception were included. EXCLUSION CRITERIA: Pregnant and lactating women, in Group 1: patients suffering from diabetes, hypertension, peptic ulcer disease, renal, hepatic, heart disease or tuberculosis, in Group 2: patients with abnormal lipid profile, diabetes, hypertension, renal, liver or heart disease were excluded. RESULTS: out of 60 patients enrolled in study, 2 patients from group 1 and 5 patients from group 2 were dropped from study and results were concluded. Majority of patients were in age group of 31-60 (78.3%) with male to female ratio of 2.1:1.Group 1 patients at the end of 8 weeks response was seen in 92.8%, with relapse rate of 15.38% after 6 months of follow up. Group 2 patients at end of 8 weeks response was seen in 72 % with relapse rate of 5.5%. CONCLUSION: In our study oral mini pulse therapy with betamethasone has early onset of action and with a complete response in majority of patients with slightly more relapse rate when compared to oral acetretin. Oral acetretin has less relapse rate due to prolonged half-life.