Objective: To develop and validate simple, rapid, linear, accurate, precise and economical UV Spectroscopic method for estimation of Lamivudine in tablet dosage form. Methods:The drug is freely soluble in analytical grade water. The drug was identified in terms of solubility studies and on the basis of melting point done on melting point apparatus of Equiptronics. It showed absorption maxima were determined in analytical grade water. The drug obeyed the Beer's law and showed a good correlation of concentration with absorption which reflects in linearity. The UV spectroscopic method was developed for estimation of lamivudine in tablet dosage form and also validated as per ICH guidelines. Results:The drug is freely soluble in analytical grade water, slightly soluble in methanol and practically insoluble in acetone. So, the analytical grade water is used as a diluent in the method. The melting point of lamivudine was found to be 160-161˚C (uncorrected). It showed absorption maxima 268 nm in analytical grade water. On the basis of the absorption spectrum, the working concentration was set on 10µg/ml (PPM). The linearity was observed between 6-14 μg/ml (PPM). The results of the analysis were validated by recovery studies. The recovery was found to be 98.7, 101 and 99.2% for three levels respectively. The % RSD for precision was found to be 0.62%. Conclusion:A simple, rapid, linear, accurate, precise and economical UV Spectroscopic method has been developed for estimation of Lamivudine in tablet dosage form. The method could be considered for the determination of Lamivudine in quality control laboratories.

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A simple and reproducible method was developed for carbimazole by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). Carbimazole was separated on C 18 column [4.6x250mm, particle size 5μm] at the UV detection of 291nm. Methanol and OPA (0.1%) was used as a mobile phase with various ratios and flow rates, eventually 80:20 v/v Methanol and OPA (0.1%) was being set with the flow rate of 0.7mL/min. The statistical validation parameters such as linearity, accuracy, precision, inter-day and intra-day variation were checked, further the limit of detection and limit of quantification of carbimazole concentrations were found to be within the limits. Recovery and assay studies of carbimazole were within 99 to 102% indicating that the proposed method can be adoptable for quality control analysis of carbimazole.