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Ameloblastoma has been described by Robinson as a tumor which is “usually unicentric, nonfunctional, intermittent in growth, anatomically 1 benign and clinically persistent” .It mostly occurs in second and third decades of life but it can be seen in children. It is usually asymptomatic for a 4 long period, slow growing, aggressive, locally invasive tumor with multiple histological variants and high recurrence rates . The term Unicystic Ameloblastoma (UA) refers to those cystic lesions that show clinical and radiological characteristics of an odontogenic cyst but on histological 6 examination show a typical ameloblastomatous epithelium, lining part of the cyst cavity, with or without luminal and/or mural tumor growth. Unicystic ameloblastoma (UA) is an uncommon variant of ameloblastoma and behaves totally different from the solid multicystic variant of 7 ameloblastoma (SMA). Here, we report a case of unicystic ameloblastoma which was misdiagnosed radiographically as dentigerous cyst in a 29-year-old female with a review of the literature.