Introduction: The longevity of the population observed in the last decades, associated with the growth of chronic-degenerative diseases has increased the need for polytherapy in the elderly population. Studies show that each elderly person uses an average of four to six medications, which increases with age, characterizing a complex therapy that needs pharmacotherapeutic follow-up to avoid the occurrence of problems related to the use of medications (PRM). Objective: To analyze the pharmacotherapy of patients assisted by a long - term institution located in the city of Montes Claros - MG. Methodology: The study presents a transversal and descriptive character. The data were obtained from a clinical interview with the application of a Standardized Form by the Federal Council of Pharmacy for Pharmaceutical Consultation, analysis of medical records and patient records, after proper approval by the Ethics and Research Committee. Results and Discussion: During the study the pharmacotherapy of 40 elderly patients was analyzed, A total of 145 drug - related problems (DRPs) were identified and classified into 14 categories, with the most frequent being drug - drug interaction, inadequate frequency or times of administration, drug - food interaction and inappropriate or contraindicated drug prescription ( 10%). Conclusions: It was concluded that a great number of problems related to the use of drugs were detected, putting at risk the health of the elderly.