Transfusion transmitted infections (TTI) are still prevalent in our country, even in 21st century. The aim of this study was to identify the infections in blood donors. Blood samples from blood donors collected for over a Material and methods: period of 3 years were screened for Human Immuno-deciency (HIV) antibodies, Hepatitis B Virus (HBV) antigen, Hepatitis C Virus (HCV) antibodies and Treponema antibodies. Details of donors were noted. Results: Total of 4168 blood donors were screened among which there was predominance of replacement donation (90.21%) and male sex (93.64%). In this study, Infection rate of HIV was 0.34% HBV was 1.92%, HCV was 0.10% and Syphilis was 0%. In this study, total infection rate was 2.35%. Henc Conclusion: e, strict screening of Blood for viruses and bacteria is required to prevent the recipient from getting infected.