Despite serious safety concerns, Calotropis procera is used for gastrointestinal disorders. The subterranean termites Odontotermes obesus is extremely invading wood pests that cause direct economic losses worth billions of dollars throughout the world particularly in humid and subtropic regions. Leaf extract of Calotropis procera in two solvent hexane and acetone, is used against workers of subterranean termites, mortality. LC50 and tunneling behavior of termites was observed at different concentration of 3%, 7% and 10% respectively and distilled water applied a control. Two solvent hexane and acetone is used for extraction. Data have been analyzed using software Minitab (version 16).