Purpose -This study aims to explore the barriers to implementation of ISO 9000 in China, and to identify how these barriers can be overcome. Design/methodology/approach -Using a structural questionnaire survey, this paper examines the main barriers for enterprises in effective implementation of the ISO 9001 standard. Findings -This paper highlights the problems in implementing the standard, which determines the sustainable implementation, including: short-sighted goal for "getting certified"; over-expectation on the ISO 9001 standard; mandatory requirement (not wholehearted commitment) in some industries; and following others (the trend) in certification. With regard to the effective audit of the ISO 9001 standard, the main problems were explored, including: lack of commitment from some certifying bodies; excessive competition between certifying bodies; and offering of a total packaged service from consultancy to certification by certifying bodies. Practical implications -The ISO 9000 series have permeated into all industrial sectors. Although there are many stories of successful adoption of ISO 9001, problems in implementing the standards need to be explored, which may affect the sustainable implementation. Originality/value -Based on the analysis, the paper proposes that the government should improve the legal framework and enforcement schemes to strengthen supervision and control for effective auditing of ISO 9000 standards.

PurposeThe aim of this study is to evaluate implementation of an integrated management system (IMS) based ISO 9001 and ISO 14001 standards for construction firms.Design/methodology/approachSupported by a structured questionnaire survey, this paper examines several related issues in the implementation of IMS in construction firms in China. The researchers interviewed the auditors of ISO 9001 and ISO 14001 standards and senior managers of ten construction firms. The structured questionnaires were sent to 300 construction firms in China. Among them, 68 completed questionnaires were received.FindingsThe findings reveal that a majority of the firms support an integration of the ISO 9001 and ISO 14001 standards. “Similarity” and “compatibility” between the two standards are considered as the main reasons for pursuing such an integration. The benefits resulted from the integration include “avoidance duplication of procedures”, “reduced conflict of procedures”, and “reduced requirements for resources”. The research also finds that organizations need technical guidance and support from certifying bodies to complete the integration.Practical implicationsProposes some useful suggestion for the contractors which are implementing (or will implement) both ISO 9001 and ISO 14001 standards.Originality/valueIt provides a possible solution by IMS with combining ISO 9001 and ISO 14001 for the contractors which are implementing (or will implement) both ISO 9001 and ISO 14001 standards. The IMS could help the contractors to overcome the challenges faced by them and achieve continual improvement.

Noninvasive genotyping of driver genes and monitoring of tumor dynamics help make better personalized therapeutic decisions. However, neither PCR-based assays nor amplicon-based targeted sequencing can detect fusion genes like anaplastic lymphoma kinase (ALK) rearrangements in blood samples. To investigate the feasibility and performance of capture-based sequencing on ALK fusion detection, we developed a capture-based targeted sequencing panel to detect and quantify rearrangement events, along with other driver mutation variants in plasma. In this perspective study, we screened 364 patients with advanced non-small cell lung cancer (NSCLC) for ALK rearrangements, and collected blood samples from 24 of them with confirmed ALK rearrangements based on their tissue biopsies. ALK rearrangements were successfully detected in 19 of 24 patients at baseline with 79.2% (95% CI 57.9%, 92.9%) sensitivity and 100% (36/36) specificity. Among the 24 patients, we obtained longitudinal blood samples from 7 of them after either chemotherapy and/or Crizotinib treatment for disease monitoring. The by-sample detection rate of ALK rearrangements after treatment drops to 69.2% (9 of 13). In addition to detecting ALK rearrangements, we also detected 3 Crizotinib resistant mutations, ALK L1152R, ALK I1171T and ALK L1196M from patient P4. ctDNA concentration correlates with responses and disease progression, reflecting its ability as a biomarker. Our findings suggest capture-based sequencing can detect and quantify ALK rearrangements as well as other somatic mutations, including mutations mediated drug resistance, in plasma with high sensitivity, paving the way for its application in identifying driver fusion genes and monitoring tumor dynamics in the clinic.