Chlorpyrifos is a broad-spectrum organophosphate pesticide widely used for agricultural and nonagricultural applications that can highly intervene and impact with the ecosystem and affects both biotic and abiotic components. Photocatalytic degradation process using nanoparticles and nanocomposites are more fascinating as they are rapid and e cient than the existing other degradation routes. In this study, Curcubita maxima leaves are used as a novel source for green synthesis of reduced graphene oxide -silver composite in a single pot. Characterization of the novel phyto source driven composite was performed by UV-visible spectroscopy, Fourier transform infrared analysis, X-ray diffraction analysis and eld emission scanning electron microscopic methods. The assessment of degradation effect of chlorpyrifos by the synthesized nanocomposite was performed. The photocatalytic activity of the composite was demonstrated through two different process as adsorption under room temperature and photocatalysis in the presence of sunlight. Different parameters such as pH, time, photocatalyst dose and pesticide concentration were optimized. The adsorption isotherms governing the photocatalytic adsorption process were investigated to predict the adsorption capacity of the synthesized nanocomposite. In addition, the results of antimicrobial activity of the nanocomposite against grampositive, gram-negative bacteria and antifungal activity were also been found to be highly promising to utilize this composite for the removal of microbial contaminations in wastewater treatment.