Thalidomide (α-N-[phthalimido] glutarimide, C13 H10 N2 O4), is a glutamic acid derivative initially introduced as a sedative hypnotic nearly forty years ago. It was withdrawn following numerous reports linking it to a characteristic pattern of congenital abnormalities in babies born to mothers who used the drug for morning sickness. It has gradually been re-introduced into clinical practice over the past two decades, albeit under strict regulation, since it was found to be broad spectrum of anti-cancer activity. Anti-tumor activity of thalidomide may be related to a number of known properties, including anti-tumor necrosis factor (TNF)-α and T-cell co-stimulatory and anti-angiogenic activities. Nanoemulsions of thalidomide were prepared in the form of intravenous injection for the treatment of cancer. The therapeutic potential of thalidomide provided motivation to develop more effective derivatives with considerably reduced toxicity. There are two types of thalidomide's immunomodulatory (IMiDs) analogs are lenalidomide and pomalidomide represent a novel class of compounds with numerous effects on the immune system. These analogs are thought to mediate the anticancer and anti-inflammatory effects observed in humans. Thalidomide is currently approved for the treatment of dermal reaction to leprosy and is currently in phase III trials for multiple myeloma (MM). IMiDs inhibit the cytokine's tumor necrosis factor-α (TNF-α), interleukins (IL) 1 α, 6, 12, and granulocyte macrophage-colony stimulating factor (GM-CSF). The repression of the tumor necrosis factor-a (TNF-a) expression is the crucial factor of many of the anti-inflammatory properties of thalidomide.

This study assessed the effect of e-taxation on revenue generation in Anambra state. Specifically, the study intends to; examine the effect of e-taxation on tax revenue generation in Anambra state; determine whether the adoption of etaxation has reduced tax malpractice in Anambra state and ascertain the tax revenue improved based on the e-taxation adoption in Anambra state. Survey design was employed. Data collected were analyzed and one sample t-test was used to test the formulated hypotheses. The study found that E-taxation has effect on tax revenue generation in Anambra state and adoption of e-taxation has reduced tax malpractice in Anambra state. Another finding is that tax revenue has improved based on the adoption of e-taxation in Anambra state. Based on this, the researchers recommended among others that well-equipped database on tax payers should be established by the governments with the aim of identifying all possible sources of income of tax payers for tax purpose.

The polycystic ovary disorder (PCOS) is characterized as a mix of hyperandrogenism (hirsutism and skin break out) and anovulation (oligomenorrhea, barrenness, and useless uterine seeping), with or without the nearness of polycystic ovaries on ultrasound. It speaks to the primary endocrine issue in the conceptive age, influencing 6% -15% of ladies in threats. It is the most widely recognized reason for barrenness because of anovulation, and the primary wellspring of female fruitlessness. At the point when in the pre-since of a menstrual issue, the finding of PCOS is come to in 30% -40% of patients with essential or auxiliary amenorrhea and in 80% of patients with oligomenorrhea. PCOS ought to be analyzed and treated right off the bat in pre-adulthood because of conceptive, metabolic and ontological difficulties which might be related with it. Treatment choices incorporate medications, diet and way of life improvement. For solid youthful couples, the probability of getting pregnancy differs. In 2010, an expected 48.5 million couples worldwide were barren. This paper gives a survey on barrenness causes, examinations, treatment modalities and job of medical attendant birthing specialist in managing fruitless couples. Barrenness (a condition of sub richness) can be showed either as the failure to wind up pregnant, powerlessness to maintain a pregnancy, and failure to proceed with a pregnancy till term. There are different reasons for female and male fruitlessness.