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Artificial intelligence (AI) analyses real-time human-machine and machine-machine data flows. AIoT—artificial intelligence, the internet of things, and mental health well-being—is the digital age's main need. AI and data from connected sensors and actuators reduce latency, increase privacy, and provide real-time edge intelligence, helping the Metaverse technology support mental health for certain age groups and patients. Metaverse technology can boost brain and mental health. Metaverse technology and brain health are covered in this chapter. Metaverse technology can improve mental health virtual reality research, the chapter says. The chapter examines metaverse technology's ethical and social effects on mental health. This chapter examines how AIoT with metaverse can improve mental healthcare using virtual reality and other methods, focusing on brain and mental healthcare technologies, prospective applications, and related research. This research will provide AIoT-enabled brain and mental healthcare standards policy options which may be adopted in future.