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A new method is described for the facile alkylation of uracil nucleotides. Treatment of the unprotected nucleotide with mercuric acetate followed by the addition of styrene or ring-substituted styrenes and lithium tetrachloropalladate affords the C-5-trans-styryl derivatives. The coupling reactions using nucleosides or nucleotides proceed in moderate to good yield, can be run in protic solvents, are not adversely affected by the presence of the phosphate group or sugar hydroxyls, and are compatible with nitro, amino, and azido substitution of the phenyl ring in styrene.

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