Efficient access to 8 H -isoquinolino[1,2- b ]quinazolin-8-ones and phthalazino[2,3- a ]cinnoline-8,13-diones through cyclic amide-directed Ru(II)/Ir(III)-catalyzed C–H bond activation, has been developed. Consecutive C–H bond activation, carbene insertion, and condensation annulation processes were realized, affording 8 H -isoquinolino[1,2- b ]quinazolin-8-one and phthalazino[2,3- a ]cinnoline-8,13-dione derivatives in good-to-excellent yields under mild conditions, with H 2 O and N 2 being generated as the only byproducts.

Access topyrazolo [3,4-b]pyridines through a rhodium-catalysed intermolecular cyclization of pyrazol-5-amine and cyclic 1,3-diketone-2diazo compounds, has been developed. A methyl carbon of N,N-dimethylformamide (DMF) performed as a carbon-hydrogen source for the construction of the pyridine ring. Various pyrazolo [3,4b]pyridine derivatives were obtained under mild conditions using air as the terminal oxidant.

A mild and eco-friendly visible-light-induced direct radical cross-coupling perfluoroalkylation of the imidazo[1,2-a]pyridines with perfluoroalkyl iodides was established. This method leads to a facile and practical synthesis of valuable 3-perfluoroalkyl substituted...

Efficient and practice access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C–H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed.

A novel divergent synthesis of multi-substituted isoquinolines via C(sp3)–C(sp3) bond cleavage rearrangement reactions was realized.