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AntibioticGE2270A inhibits bacterial protein biosynthesis by acting on EF-Tu1 "4*. The antibiotic has a thiazolyl peptide structure5* which has been recently revised6'7*. Other structurally related antibiotics are normally co-produced with GE2270Aby Planobispora rosea ATCC 53773. We describe the isolation and characterization of GE2270 factors E, Dl, D2, Cl, C2a, C2b, Bl, B2 and T.Crude preparations from fermentations of Planobispora rosea ATCC53773 were obtained (Scheme 1) which were enriched in the factors co-produced with GE2270A.

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