A 60-year-old woman underwent polycaprolactone-based filler injection in her midface. Four months later, she developed progressive swelling of midface after a self-limiting viral gastroenteritis. The diagnosis was "delayed-onset immunemediated nodule formation triggered by a virus." Ultrasonography enabled us to efficiently treat her with a tailored intralesional corticosteroid injection method.

With advances in the ultrasound-assisted esthetic procedures, filler injection can successfully be used for cosmetic correction of face structural imperfections.Here, we present a new filler injection method by targeting two anatomic landmarks which effectively improved the appearance of a mandibular prognathism case who was a maxillofacial cosmetic surgery candidate.