Letter to editor Eugenol (4-allyl-2-methoxy phenol) is a phenolic compound of the clove family Syzygium aromaticum (L.) Merr. & L.M.Perry. In traditional and modern medicine, clove oil has been used as an antimicrobial, antiseptic, antispasmodic, antioxidant, anti-inflammatory, anesthetic, anticarcinogenic, neuroprotective ability, hypolipidemic efficiency, and antidiabetic effect, induce apoptosis by destruction the mitochondrial membrane and production of reactive oxygen species, household products, fragrance in soaps and cosmetics, skincare products, flavoring substances for food, dental and pharmaceutical products and etc.

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In recent decades, some 30 new human pathogens have been identified, of which 75% were spillovers from animals. In late 2019, human infections with a new coronavirus from an unknown origin emerged in China and later spread worldwide. The zoonotic source of severe acute respiratory syndrome coronavirus 2 remains unknown, and there is only some limited information about the close association between the first human cases of COVID-19 and visiting animal markets. Now, bats and pangolins are suspected as natural hosts, and large cats, raccoon dogs, dogs, minks, ferrets, and pangolins as intermediate hosts. There is not enough evidence to prove that animals can transmit COVID-19 infection to humans, but there are some data about the transmission of SARS-CoV-2 between humans and some animal species.