BackgroundStroke, or cerebrovascular accident (CVA), is the second leading cause of death in the world and based on the World Health Organization (WHO) report in 2006, it is responsible for 9.9% of all deaths in the world which over 85% of these deaths occurred in developing countries.ObjectivesThe aim of this study was to investigate the data related to the frequency, risk factors, types and mortality of stroke in Birjand city.Patients and MethodsA retrospective cohort of consecutive patients with diagnosed stroke who were admitted to hospital (the only neurological center of Birjand) between 2002 and 2008 was designed. A stroke was defined according to clinical features and CT-scan which was confirmed by agreement of a staff neurologist. Collected data included date of admission, age, sex, and hospital outcome as well as related risk factors.ResultsTotally, 1219 stroke (85.4% ischemic type) with the mean age of 69.6 ± 12.9 years and female: male ratio of 1.09 was included in over 6 years. The stroke hospital admission rates were 48.6 and 103.4 /100,000 population /year in the first and the last year of the study, respectively. There was an increasing trend in stroke incidence rate during the study (P < 0.01). The most common epidemiological risk factors for stroke in our region were hypertension, cardiac diseases, a history of stroke, diabetes mellitus, dyslipidemia, and smoking (54.7, 24.4, 20.1, 14.9, 12.2, and 9%, respectively). Overall in-hospital mortality rate was 17.1%.ConclusionsThe stroke hospital admission rate might be increasing in Birjand. Therefore, health care administrators and public health authorities must work harder to promote the knowledge and practice of society about the stroke related risk factors and prevention methods.

Introduction:Pituitary adenomas have been the most common sellaturcica tumors. There have been many unusual types of pituitary tumors that might neglect by radiologists and clinicians. One of these tumors would be the malignant glioma.Case Presentation:A 62-year-old male has complained from sudden frontal headache, nausea, vomiting, decreased vision, blurred vision and double vision. In skull radiographic, there was an expansion of sellaturcica and a lesion with clear border on T1; heterogeneous; iso - to hypotense; size about 3/5 × 2/5 cm with no surrounding edema that it has homogeneously attracted contrast Lesion, that shown a signal hypointensity on T2 with heterogeneous enhancement. In the coronal sections, the tumor expanded to the suprasellar region and optic chiasmatic that has compressed especially on the left side. Partial tumor resection has conducted. The surgery has done by a transsphenoidal approach. The pathologist has diagnosed a glioblastoma. This diagnosis has confirmed using immunohistochemistry technique.Conclusions:There have been many unusual types of pituitary tumors that might neglect by radiologists and clinicians. One of these tumors would be the malignant glioma.

Intrahepatic lesions of hepatocellular carcinoma (HCC) have been controlled by significant advances in treatment, including chemotherapy, surgery, and ablative therapy. Consequently, the number of patients with extrahepatic metastatic lesions has increased, including lung, regional lymph nodes, peritoneum, and adrenal glands, but rarely to the brain. The prognosis of brain metastasis remains poor, with approximately <1 y of survival from the time of diagnosis. Although no guidelines for the brain metastasis of HCC have been developed to date due to the lack of the experiences and pieces of evidence, a molecularly targeted drug, sorafenib, have been used to treat extrahepatic lesions and shown the prolonged survival time. Therefore, the development of standard therapy for brain metastasis following the early diagnosis is essential by accumulating the information of clinical courses and pieces of evidence.

Although the most common site in Non-Hodgkin's Lymphoma (NHL) is the Waldeyer’s ring, the involvement of the tongue is extremely rare. The present study revealed a 70-year-old female with primary non‑Hodgkin’s lymphoma (NHL) of the base of the tongue with the chief complaint of sore throat and dysphasia as a rare case report. The patient was expired 3 months after diagnosis because of the advanced stage of the disease and poor physical statue. The diagnosis was confirmed as primary NHL diffuse large B cell type by histopathological and immunohistochemistry results

Abstract- Krukenberg tumors are rare metastatic ovarian tumors with its primary site being the gastrointestinal tract as a most common site and poor prognosis. We hereby, present a 25-year-old pregnant female suffering from abdominal pain and iterative vomiting episodes. She was diagnosed with a terminal stage of the malignant disease. She underwent total ovariectomy without any radiotherapy. Histological examination of the specimen yielded diagnosis of Krukenberg tumor. Ten days later, the patient underwent a natural vaginal delivery in the 25th gestational week because of labor pain, and we extracted a dead male newborn of 31 cm, 510 g, AP score 0. Three weeks later, the patient died because of pulmonary failure