At present time, the competition in the health care market intensifies, and health care institutions have tried to improve the efficiency and competitive advantages of their institutions by improving the cost-effectiveness and quality of care. Here, we aimed to determine the relationship between the levels of ISO 2008 -9001 quality management system with change of indictors of quality effectiveness from the provision of staff in hospitals of Rasht. This cross-sectional study was performed in three ISO-certified hospitals of Rasht, 352 people were considered in current study, during2014.The data of this research was collected through self-regulation questionnaire, by measuring its criterion related validity and content validity. In addition, Cronbach coefficient alpha was applied to confirm the reliability of the given data. Data of quality effectiveness indictors were compared by using T-test before and after the implementations. Furthermore, analysis was follow out by Pearson correlation coefficient. There was a significant relationship between the implementations and some indicators of quality effectiveness (r= %58, p<0.05). No significant differences were observed between the length of stay of patients in hospitals before and after the deployment (p>0.05, t=0.08). We found that 72.4% of the staff disagrees with the impact of implementations on bed occupancy, while 83.8% of the staff disagrees with average length of patients stay. Using an integrated quality management model which can offer a program for the continuous improvement of quality in addition to being able to identify the exact quality needs in medical and healthcare fields would impact on medical indicators of the quality effectiveness in hospitals.