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Perchlorate ions ClO4(-), known to inhibit competitively the uptake of iodine by the thyroid, have been detected in drinking water in France as well as in infant formulae. A tolerable daily intake (TDI) has been established at 0.7 µg kg(-1) bw day(-1) based on the inhibition of iodine uptake. Due to this mechanism of action, the iodine status could strongly influence the biological effect of perchlorate. Perchlorate concentrations in water and infant formulae were measured and the exposure of children under 6 months of age calculated. It appeared that the TDI could be exceeded in some children. As the iodine status is not optimal within the entire French population, there appears to be a need to clarify the sources of perchlorate ultimately to decrease exposure.

L’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail (Anses) résulte de la fusion, intervenue le 1 er juillet 2010, de l’Agence française de sécuritaire sanitaire des aliments (Afssa) et de l’Agence française de sécurité de l’environnement et du travail (Afsset). En reprenant les missions de ces deux entités, l’Anses offre une lecture transversale des questions sanitaires et appréhende de manière globale les expositions auxquelles l’Homme peut être soumis au travers de ses modes de vie et de consommation, ainsi que les caractéristiques de son

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