Trans-resveratrol, total antioxidant capacity (TAC), and total phenolic compounds were assessed in Bolivian grape cultivars collected at high altitude valleys. The TAC of the grapes ranged from 0.8 to 22 µmol Trolox equivalents/g dry matter determined by 2,2 -azino-bis(3-ethylbenzthiazoline-6-sulphonic acid), and from 0.6 to 10 determined by the ferric reduction antioxidant power. In the present study, we observed that under certain conditions trans-resveratrol levels in Bolivian grapes are 10-fold higher than the reported data from the literature. Additionally, the temporal evolution in three different solar ultraviolet-B radiation levels was carried out to understand their effect on the oxidative processes.