Abdominal aortic aneurysm (AAA) can be defined as a permanent and irreversible dilation of the infrarenal aorta. AAAs are often considered to be an aorta with a diameter 1.5 times the normal infrarenal aorta diameter. This paper describes a technique to manufacture realistic silicone AAA models for use with experimental studies. This paper is concerned with the reconstruction and manufacturing process of patient-specific AAAs. 3D reconstruction from computed tomography scan data allows the AAA to be created. Mould sets are then designed for these AAA models utilizing computer aided designcomputer aided manufacture techniques and combined with the injection-moulding method. Silicone rubber forms the basis of the resulting AAA model. Assessment of wall thickness and overall percentage difference from the final silicone model to that of the computer-generated model was performed. In these realistic AAA models, wall thickness was found to vary by an average of 9.21%. The percentage difference in wall thickness recorded can be attributed to the contraction of the casting wax and the expansion of the silicone during model manufacture. This method may be used in conjunction with wall stress studies using the photoelastic method or in fluid dynamic studies using a laser-Doppler anemometry. In conclusion, these patient-specific rubber AAA models can be used in experimental investigations, but should be assessed for wall thickness variability once manufactured.

While Type Ia Supernovae (SNe Ia) are one of the most mature cosmological probes, the next era promises to be extremely exciting in the number of different ways SNe Ia are used to measure various cosmological parameters. Here we review the experiments in the 2020s that will yield orders of magnitudes more SNe Ia, and the new understandings and capabilities to constrain systematic uncertainties at a level to match these statistics. We then discuss five different cosmological probes with SNe Ia: the conventional Hubble diagram for measuring dark energy properties, the distance ladder for measuring the Hubble constant, peculiar velocities and weak lensing for measuring σ 8 , and strong-lens measurements of H 0 and other cosmological parameters. For each of these probes, we discuss the experiments that will provide the best measurements and also the SN Ia-related systematics that affect each one.

Biofeedback therapy can be effective in children with dysfunctional voiding and urinary tract infection. Children with a staccato voiding pattern may require a minimum of 3 visits to improve the voiding pattern. Children who complete 3 sessions are more likely to succeed.

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