Abstract. Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal activity against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). Quinoline functionalized phosphonium has shown more antibacterial activity than pyrazine and quinoxaline. IntroductionRecently, more attention towards to positively charged compounds such as quaternary ammonium and phosphonium salts for the application as disinfectants in agriculture, the food processing industry and clinics etc. Because of owing high antibacterial and a broad spectrum of antimicrobial activity, these organic cations are particularly important to act as disinfectants. Quaternary ammonium compounds are actively prevented the growth bacterial growth against both Gram-positive and Gram-negative bacteria, as well as against other pathogenic species of fungi and protozoa [1]. It has been found that quarternary phosphonium salts also showed beneficial antibacterial activity [2,3].Microbial protection is mainly dependent on long alkyl chains which are attached with the phosphonium salts. These can be enhanced strongly by the molecular structure, correlation between antimicrobial activity and molecular structure [4]. It is significant that the double decyl groups of phosphonium biocide exhibited the broadest spectrum of microbial activity and showed the greatest bacteriostatic activity against MRSA infection. It was determined that the phosphonium salts showed better bactericidal activity and killing rate than corresponding ammonium salts [5]. On the other hand, higher cytotoxicity and complimentary selectivity of few cancer cells was detected towards for the derivative of mono and di phosphonium salt [6]. Shtyrlin et al synthesized the pyridine and pyridoxine analogue of quaternary phosphonium salts with excellent antibacterial and cytotoxic activities [7].Based on these observations, azine heterocycles of pyrazine, quinoxaline, and quinoline was bromo methylated and converted to quaternary phosphonium salts. These compounds was well 2

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