Objective: To evaluate the effects of calcium carbonate and calcium gluconate on acute and subacute inflammation, and to study their possible interactions with aspirin, verapamil and magnesium sulphate. Materials and Methods: Calcium carbonate in the dose of 10, 25, 50 mg/kg, calcium Department of Pharmacology and gluconate in the dose of 5, 10, 25, 50 mg/kg, and aspirin in the dose of 54, 200 mg/kg Pharmacotherapeutics, were administered orally in different groups of albino rats, to study their effect on J.N. Medical College, inflammation induced by carrageenan or a foreign body. Aspirin (54 mg/kg) was Nehru Nagar, administered either with calcium carbonate (10 mg/kg) or calcium gluconate (5 mg/kg) Belgaum-590 010. India to separate groups in order to study their interaction, especially with reference to gastric

Wound healing, a common clinical entity contemporary to human beings, has been recognized to be influenced by several factors such as nutrients like vit-C, zinc, and hormones like GH, insulin, etc. Products of traditionally used plants such as Bryophyllum pinnatum [1] and Moringa oleifera [2] have also been reported to promote healing in experimental animals, probably by virtue of their antimicrobial activity. Because it is well known that infection interferes with healing, antimicrobials are expected to suppress infection and promote healing process only in infected wounds. Antimicrobials are routinely administered pre-and post-surgically and metronidazole, a commonly used antiprotozoal for surgical chemoprophylaxis against anaerobes, is likely to influence the surgical outcome. However, metronidazole (MTZ) has been reported to delay the healing process in dead space wounds [3] and reduce the breaking strength of facial wounds. [4] Recently, MTZ has been reported to possess a potent anti-oxidant property that augments healing process in burns. [5] Similarly, tinidazole (TNZ) has also been reported to suppress healing of dead space wounds, [3] whereas fluconazole (FLZ), a related antifungal azole, has been shown to enhance epithelization. [13] There are no reports on the influence of ketoconazole (KCZ) on wound healing, an antifungal related to fluconazole.

Objectives: Objectives: The present study was planned to explore the genotoxicity of morphine, buprenorphine, pentazocine, and noscapine. Materials and Methods: Materials and Methods: Bone marrow micronucleus assay and single cell gel electrophoresis assay were employed after 24 h (single dose) and 72 h (three doses) of treatment with clinically equivalent doses of opioids in albino mice. Percentage of micronucleated polychromatic erythrocytes and comet tail length were determined and the results were analyzed by one-way ANOVA and Student's 't' test. Results: Results: Only morphine and noscapine showed significant (P < 0.01) increase in both the number of micronucleated polychromatic erythrocytes and comet tail lengths in acute (24-h) as well as subacute (72-h) studies. Conclusions Conclusions: These results clearly indicate the genotoxic potential of morphine and noscapine at the clinically equivalent doses.

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