Objective: to understand the meaning of work, from the perspective of nursing professionals. Methods: qualitative research, conducted in a clinical inpatient unit of a university hospital. The study included 20 nursing professionals contacted through semi-structured interviews. The data were analyzed through the thematic content analysis technique, emerging the categories: perspectives and meanings attributed to the world of work by nursing professionals and situations that cause pleasure and suffering and their influences in the health-disease process of workers. Results: one identified positive and negative aspects inherent to the nursing work in the hospital environment and highlighted the illness that comes with the working process. Conclusion: the experiences of pleasure and pain are inherent to the context of nursing professionals who work in hospital environments and contribute to a search for better conditions of work place and quality of life for these professionals. Descriptors: Nursing; Work; Occupational Health. Objetivo: compreender o significado do trabalho, sob a ótica de profissionais de enfermagem. Métodos: pesquisa qualitativa, realizada em unidades de internação clínica, de hospital universitário. Participaram do estudo 20 profissionais de enfermagem, abordados por meio de entrevista semiestruturada. Dados analisados mediante a técnica de análise de conteúdo temática, emergindo as categorias: perspectivas e significados atribuídos ao mundo do trabalho pelos profissionais de enfermagem e situações geradoras de prazer e sofrimento e respectivas influências no processo saúde-doença dos trabalhadores. Resultados: Identificaram-se aspectos positivos e negativos inerentes ao contexto do trabalho da enfermagem no ambiente hospitalar e evidenciou-se o adoecimento decorrente do processo de trabalho. Conclusão: as vivências de prazer e sofrimento são inerentes ao contexto do trabalho da enfermagem no ambiente hospitalar e contribuem para busca por melhorias no ambiente laboral e qualidade de vida de profissionais.
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