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The paper describes the activities of the European project SOPHIA, Socio-Physical Interaction Skills for Cooperative Human-Robot Systems in Agile Production. The consortium involves European partners from academia, research organizations and industry. Themain goal of the project is to develop a newgeneration of CoBots andWearbots and advanced instrumental-based biomechanical risk assessment tools in industrial scenarios to reduce work-related musculoskeletal disorders and to improve productivity in industry 4.0.Further aimof the project is to create the basis for newergonomic international Standards for manual handling activities.

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