The aim of this study is to examine the situations of sole proprietorship, e-commerce entrepreneurs and trends in their e-commerce. This study uses a mixed-method quantitative and qualitative approach for collecting the data. The study finds that most sole proprietorships in e-commerce are owned females between 31 and 40 years old who are educated with a Bachelor's degree (63.16%) and draw an income of 40,001-50,000 bahts per month (approximate $1 USD = 33 bahts). Most of these sole proprietorships (66.59%) are located in the central part of Thailand. These entrepreneurs spend more than eight hours a day on their businesses and supply their products by themselves. However, most of the problems faced by these sole proprietorship, e-commerce entrepreneurs involve the cost for investment in the business and the knowledge that is required in order to be an entrepreneur. Nevertheless, the trend toward sole proprietorship, e-commerce entrepreneurs in Thailand will increase with the adaptation of mobile-commerce in Thai society.