The creation of the Enabling Technologies Consortium (ETC) is described. The ETC fosters precompetitive collaborations aimed at the development and evaluation of new enabling technologies for pharmaceutical research and development, with an initial focus on chemistry, manufacturing, and controls. An overview of the structure and function of the new organization, which will carry out its work while remaining mindful of antitrust compliance requirements, is herein presented along with a description of several ongoing development projects.

The characterization of a class of electrical circuits is carried out in terms of both stability properties and steady-state behavior. The main contribution is the interpretation of the electrical topology (how the elements that conform the circuits are interconnected) in terms of mathematical properties derived from the structure of their models. In this sense, at what extent the topology by itself defines the dynamic behavior of the systems is explained. The study is based on the graph theory allowing capturing, departing from the well-known Kirchhoff laws, the topology of the circuits into several matrices with specific structure. The algebraic analysis of these matrices permits identifying conditions that determine whether the system is stable in the sense of Lyapunov and the kind of steady-state behavior that it exhibits. The approach is mainly focused on typical topologies widely used in practice, namely, radial, ring, and mesh networks.

We studied global nonaxisymmetric hydrodynamic instabilities in an extensive collection of hot, self-gravitating polytropic disk systems, systems that covered a wide expanse of the parameter space relevant to protostellar and protoplanetary systems. We examined equilibrium disk models varying three parameters: the ratio of the inner to outer equatorial radii, the ratio of star mass to disk mass, and the rotation law exponent q. We took the polytropic index n = 1.5 and examined the exponents q = 1.5 and 2, and the transitional one q = 1.75. For each of these sets of parameters, we examined models with inner to outer radius ratios from 0.1 to 0.75, and star mass to disk mass ratios from 0 to 10 3 . We numerically calculated the growth rates and oscillation frequencies of low-order nonaxisymmetric disk modes, modes with azimuthal dependence ∝ e imφ . Low-m modes are found to dominate with the character and strength of instability strongly dependent on disk self-gravity. Representatives of each mode type are examined in detail, and torques and mass transport rates are calculated.

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La conduite instabLe Le registre relationnel L'insécurité interne La sécurité émotionnelle de base se construit fondamentalement en relation avec les premiers objets d'attachement, en particulier au cours de la phase de dépendance primaire entre le bébé et son environnement. La permanence initiale de l'objet, son adaptation précoce aux besoins physiques, affectifs et psychiques du bébé sont indispensables pour constituer cette sécurité de base. Celle-ci constitue la matrice du sentiment de permanence, de l'assurance qu'il existe des choses qui ne changent pas, des certitudes sur lesquelles on peut s'appuyer. Tous les spécialistes s'accordent pour constater un manque de sécurité interne chez les enfants instables. Une des hypothèses principales à propos de certaines instabilités est celle du lien avec des interactions précoces peu adéquates qui seraient à l'origine d'une défaillance de l'expérience fondamentale de l'omnipotence primaire. Ces difficultés entraîneraient un sentiment d'insécurité et de culpabilité chez l'enfant qui s'éprouve mauvais puisque incapable de créer un environnement adéquat. Ce sentiment d'insécurité est par ailleurs corrélé à une fragilité de l'organisation narcissique qui se manifeste par un manque d'estime de soi et de confiance devant les contraintes et les épreuves de la réalité. Cette fragilité du sentiment de permanence et de continuité de la relation va secréter des obstacles dans le processus d'individuation.