FIG. l.-Alignment of partial 16s rRNA gene sequences of Mylodon darwinii (Mylodon) and extant two-toed sloth (Choloepus). The Choloepus sequence is from Milinkovitch, Orti, and Meyer (1993). Dots represent identity to the Mylodon sequence. Note that there are no insertion/deletions.

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Analysis of the molecular basis of dominantly inherited (3-thalassemia in four families has revealed different mutations involving exon 3 of the (-globin gene. It is suggested that the phenotypic difference between this condition and the more common recessive forms of ,B-thalassemia lies mainly in the length and stability of the abnormal translation products that are synthesized and, in particular, whether they are capable of binding heme and producing aggregations that are relatively resistant to proteolytic degradation. 3924The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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