AIM:To determine whether -1195 A →G and/or -765 G →C polymorphisms in Cyclooxygenase-2 (COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. RESULTS: T h e d i s t r i b u t i o n o f t h e -

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