Thiosemicarbazones are formed by the condensation of an aldehyde or ketone with a thiosemicarbazide. They have high coordinative capacity given that they have several potential donor atoms through which they can bind to transition metals. This coordinative capacity can be increased if the R1 and R2 substituents include additional donor atoms. In addition, thiosemicarbazones as well as their semicarbazones analogues have considerable biological and pharmacological interest because of their antibacterial, antiviral and antitumor activity [1-2]. This communication includes the preparation and characterization of a series of thiosemicarcarbazones and their applications in the synthesis of palladium organometallic compounds [3-4].

Abstract:Thiosemicarbazone ligands are known for their versatility towards metal coordination, forming very stable compounds with metals such as palladium. In addition, palladium derivatives are used more often than not as catalyst in C-C cross coupling reactions like the Suzuki-Miyaura reaction, however the commercially available catalyst are not of much air or thermal stability. That is the reason why in this communication we present the synthesis, characterisation and catalytic study of a family of palladium -thiosemicarbazone compounds as an improvement to the thermal and air stability of commercial catalyst.

Abstract:The Suzuki-Miyaura cross coupling reaction is a very powerful tool for making of C-C bonds from organic halides and organoboron compounds [1]. This reaction, for which palladacycles have shown great catalytic activity [2] is widely employed in academic laboratories as well as in pharmaceutical industries to synthesize organic compounds or drugs such as Losartan [3], an antihypertensive medicine.Iminophosphoranes are organic compounds of general composition R3P=NR and can be used as in coordination and in organometallic chemistry [4]. The aim of this work is to study the catalytic activity of new palladium organometallic compounds derived from iminophosphorane ligands.

No abstract

Herein we report the design, synthesis and characterization of a series of phenylboronic cyclometallated derivatives bearing different phosphines. The compounds were prepared by reaction of cyclometallated species with different phosphine ligands and they were characterized by IR, 1 H and 31 P NMR spectroscopy.