provided to 52.0%, which is also sufficient. The percentage of carbohydrate in the diet was increased in 2 times. From micronutrients in the diet of patients was revealed lack of calcium, phosphorus, and also expressed a lack of iodine, zinc, selenium, folic acid, vitamin A, vitamin E, thiamine, Niacin. Of the required amount of 40.8 g. dietary fiber patients received a total of 8.8 grams. The value of protein in the actual nutrition of patients conforms to the standards but significantly exceeded the recommended value of FAO/WHO. ConClusions: Thus, in the actual nutrition of patients in the Oncology hospitals the energy value of the ration of dietary intake, intake of total proteins, fats, carbohydrates was low than the approved standard. Especially pronounced was the lack of dietary fiber, micronutrients. In the hospitals of Kazakhstan it is necessary to apply the methods of correction of the protein component of the diet using a composite of mixtures with a high biological value and a set of essential nutrients. PCN314 BRCA1/

UK Clinical Practice Research Datalink (CPRD). Vaccinated subjects were compared to unvaccinated subjects using piecewise Cox regression model. HZ outcomes in community setting were analyzed, including HZ, PHN and other HZ complications (i.e. neurological but not PHN, ocular, disseminated and other). Results: For the routine birth cohorts (79274 subjects), we found a VE for HZ of 76.4% (95% CI: 70.6%-81.1%) and for PHN of 68.3% (95% CI: 7.4%-89.1%) for the first 2 years of vaccination. For the subsequent 2+ years, the VE estimates of HZ was 56.1% (95% CI: 29.2%-72.7%). For the catch-up cohorts (48193 subjects), the VE estimates were comparable. We found insufficient evidence to determine the VE for other HZ complications. ConClusions: Within the total population, the HZ vaccine provided protection against HZ and PHN, but its protection declined over time.Immunosuppressed conditions need to be taken into account.