Resume. The purpose of the study is to develop mathematical and geographical corrections in the analysis of time series. Materials and methods. The paper uses the results of a long-term analysis of the physiological and demographic indicators of the population of Khanty-Mansiysk and other regions of Russia. Results. For standardization and ranking of inter-seasonal, interregional studies (physiology of movements, shift work) in chronophysiological format, we propose the use of the calculated "photoperiodic latitudinal coefficient". To improve the accuracy of the results, we propose the use of the "signal noise coefficient" in the interpretation of the results, an assessment of the "degree of polyrhythmicity" and the "rhythm instability index" in the presence of "insertion" or "quantized" rhythms.