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Nordentatin and 10 coumarin derivatives were synthesized and evaluated for cytotoxicity. Compounds 6, 7, 9 and 13 showed cytotoxicity against the NCI-H187 cell line with IC50 value ranging of 3-7 µg/mL. Among synthesized coumarins, compounds 4 and 13 demonstrated cytotoxicity against the KB cell line with IC50 values of 3.94 and 6.44 µg/mL, respectively. Fortunately, coumarins 4 and 7 may be one of the new lead compounds for the development of anticancer agents due to reason that they showed weak and inactive against normal cells.

Synthesis and Cytotoxic Activity of the Heptaphylline and 7-Methoxyheptaphylline Series. -Compounds (Va) and (XI) show cytotoxicity against the NCI-H187 cell lines, which are about 138-fold and 4-fold stronger than the ellipticine standard, respectively. In addition, compound (Va) displays cytotoxicity against KB cells about 10-fold stronger than standard ellipticine as well as weak cytotoxicity against Vero cells. -(THONGTHOOM, T.; PROMSUWAN, P.; YENJAI*, C.; Eur. J. Med. Chem. 46 (2011) 9, 3755-3761, http://dx.doi.org/10.1016/j.ejmech.2011.05.041 ; Dep. Chem., Fac. Sci., Khon Kaen Univ., Khon Kaen 40002, Thailand; Eng.) -C. Cyrus