No abstract

The purpose of the present study was to evaluate yellow mombin (Spondias mombin L.) juice as a vehicle for the Lactobacillus acidophilus NRRL B-4495 probiotic. The initial pH and fermentation temperature conditions were optimized by central composite rotational design. The beverage was evaluated for its chemical composition, bioactive properties, microbiological stability, survival in simulated gastrointestinal conditions and sensory analysis. The ideal conditions for probiotic juice production were an initial pH of 6.4 and 16 h of fermentation, with maximum viability of 12.9 ± 0.4 Log CFU/mL. The fermented juice showed a total phenolic concentration of 94.90 ± 7.12 GAE/mL and antioxidant activity, as measured by DPPH (0.31 ± 0.00 μmol TE/mL) and ABTS sequestration (2.59 ± 0.30 μmol TE/mL). Antibacterial activity could also be observed against S. aureus, E. coli and K. pneumoniae. The obtained formulation showed good microbiological stability when stored at 4ºC for 28 days. In addition, there was no significant change in viability after exposure to simulated gastrointestinal conditions. The sensory analysis showed that the probiotic beverage was not well accepted. However, the Just-About-Right (JAR) ideal scale test enabled identifying the specific attributes which need to be improved from the tasters' point of view so that it is possible to improve product acceptance.

Resumo:A Síndrome da Imunodeficiência Adquirida (AIDS) é uma pandemia causada pelo Vírus da Imunodeficiência Humana (HIV), que ao atingir o indivíduo ataca os linfócitos T CD4 reduzindo a ação do sistema imune e provocando o surgimento de doenças oportunistas. Avanços em estudos permitiram o surgimento de fármacos capazes de agir contra o vírus e possibilitar a redução de morbidade e mortalidade aos que convivem com esta doença. O objetivo do presente trabalho consistiu em avaliar qual o grau de adesão da Terapia Tripla Combinada Antirretroviral e desta forma, determinar se este fármaco é capaz de garantir qualidade de vida aos seus usuários. O método de avaliação realizou-se através do formulário Cuestionario para la Evalución de la Adhesion al Tratamiento Antirretroviral (CEAT-VHI) realizado por meio de abordagem e pedido de permissão para realização do questionário aos que convivem com HIV/ AIDS. Dos participantes da pesquisa, somando-se os graus de adesão bom/ adequado com estrito/ elevado foi obtido resultado de 54%, quanto ao parâmetro baixo o percentual foi de 46%. O presente estudo determinou que a Terapia Tripla Antirretroviral Combinada é capaz de garantir melhorias na qualidade de vida dos pacientes dos pacientes com HIV.Abstract: Acquired Immunodeficiency Syndrome (AIDS) is a pandemic caused by the Human Immunodeficiency Virus (HIV), which attacks the CD4 T lymphocytes by reducing the immune system's action and causing opportunistic diseases. Advances in studies allowed the emergence of drugs capable of acting against the virus and enable the reduction of morbidity and mortality to patients with this disease. The aim of this study was to evaluate the degree of adherence of Triple Antiretroviral Therapy and to determine if this drug is able to guarantee quality of life for its users. The evaluation method was carried in the SAE of the city Juazeiro do Norte through the Cuestionario para la Evalución de la Adhesion al Tratamiento Antirretroviral (CEAT-VHI) carried out by means of an approach and request for permission to carry out the questionnaire to living with HIV. From the participants of the research, adding the degrees of good/ adequate adherence with strict/ high were obtained result of 54%, as for the low parameter, the percentage was 46%. The study highlighted that Combined Triple Antiretroviral Therapy is capable of guaranteeing improvements in the quality of life of patients with HIV.

No abstract

The present study investigated the use of choline chloride:glycerol deep eutectic solvent as an adjuvant for tuning the ethanol extraction of astaxanthin from Litopenaeus vannamei processing residues. The adjuvant concentration did not show a clear trend on the total carotenoid, however, the addition of adjuvant proved to be advantageous in the ultrasound-assisted experiments. In order to establish a balance between total carotenoid and productivity, an operational condition with ultrasound, 5% (m/v) choline chloride:glycerol and 10 min of incubation was selected, which provided 737.69 μg g-1 total carotenoids and 32.71 μg g-1 astaxanthin. When compared to the astaxanthin standard, the shrimp residue extract obtained greater antioxidant activity in free radical scavenging tests. In addition, the shrimp residue extract dramatically reduced the dosage of norfloxacin (up to 87.5%) and gentamicin (up to 75.0%) antibiotics in tests to inhibit the growth of gram-negative bacteria.