Aim: Type diabetes mellitus T DM is a procoagulant state because it is associated with increased risk of atherosclerosis. The purpose of this study was to investigate the prevalence in thrombotic markers that lead to hypercoagulability and its association with hypertension and diabetic nephropathy DN .Objective: To determine the association of molecular markers insertion/deletion of the "CE gene Rs , CCR D Rs , and MTHFR C T Rs with hypertension and DN in T DM patients of urban areas in Costa Rica, Nicaragua, and Mexico. Materials and methods: " total ofsamples of diabetic patients were collected from Costa Rica, from Nicaragua, and from Mexico.Results: " high prevalence of "CE genotype D/D p < . and CCR p < . in T DM patients from the three different countries was found. The CCR D /D genotype was seen in the population of Costa Rica. The prevalence of hypertension was . % and nephropathy was % in overall T DM patients. " statistical association was found "CE polymorphism has significance with cardiovascular disease CVD p = . , CCR D with dyslipidemia p = ., and hypertension p = . .