The process of product design and development can be complex, especially in transdisciplinary practice. A design framework is often adopted to better govern this process. In recent years, there is a growing trend for domestic devices promoting health enhancement. However, due to its specific functionality and a strong need for safety emphasis, domestic health enhancement devices need to be distinguished from other domestic consumer products from the initial stages of designing. Therefore, this study aims to explore the influence of design principles on the artefacts by developing a framework for the design and development of domestic health enhancement devices. It adopts the approach of targeting a selected lifestyle or demography and tailoring a set of device functionalities to its needs. Throughout the process, the proposed framework provides disciplined guidelines to achieve its three design objectives – safety, effectiveness, and user receptiveness. A case study is performed to demonstrate the application of the proposed framework in the context of high heel wearers. The sensor-based real-time feedback is integrated into the user involved design process. The first design iteration in accordance to the framework is completed and evaluated.