Allupurinol is a commonly prescribed drug. However, the use of this drug is not based on evidence and guidelines. We audited Allopurinol prescriptions in patients aged 65 years and over in a teaching hospital over 22 weeks. In 47% of patients the dose was higher than recommended and in 40% it was lower. Quality use of medications is an important issue to maintain quality of life in the elderly.

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ExtractThis study reports the effect of varying specific parameters of mechanical ventilation on aortic PO, in six infants with severe respiratory distress syndrome. Twenty-seven studies were performed during the first 168 hours of mechanical ventilation. I n each study, arterial oxygen partial pressure was found to vary directly with airway pressure a n d inversely with respiratory rate. No correlation was found between rate and pressure, or PaO,, PaCO,, a n d p H a . Oxygenation of infants with severe respiratory distress syndrome can be significantly influenced by variation of specific parameters of mechanical ventilation independently of change in aortic carbon dioxide tension.

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