A non-autonomous almost periodic prey-predator system with impulsive effects and multiple delays is proposed in this paper, Holling's type-IV systems and ratio-dependent functional responses are also involved in the model. By applying absolute inequalities, integral inequalities, differential inequalities and the mean-value theorem and other mathematical analysis techniques, we obtain some sufficient conditions which guarantee the permanence of the system. Moreover, we obtain the existence and the uniqueness of the almost periodic solution which is uniformly asymptotically stable by constructing a series of Lyapunov functionals. Finally, we present several numerical examples to verify the theoretical results and present some discussions of pest management in the agricultural ecological system.