Skeletal metastases are often not demonstrable in the roentgenogram until bone destruction is considerable. This applies particularly to the spine. A comparison between roentgen and postmortem findings, as well as experimental studies by BABA~ANTZ, have shown that the bone decalcification must reach about 50 yo before it is evident in the roentgen film.

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Skeletal metastases are often not demonstrable in the roentgenogram until bone destruction is considerable. This applies particularly to the spine. A comparison between roentgen and postmortem findings, as well as experimental studies by BABAIANTZ, have shown that the bone decalcification must reach about 50 % before it is evident in the roentgen film.Investigations with so-called osseophil isotopes in recent decades have contributed considerably to our knowledge of the mineral metabolism of the skeleton. Such isotopes have also been used in the elaboration of methods enabling an earlier diagnosis of osseous tumours. The distribution of radiogallium (Ga 66 , Ga 6 7 and Ga 7 2 ) in the skeleton and their concentration in osseous lesions, particularly tumours, have been studied by DUDLEY et coll. (1950DUDLEY et coll. ( , 1956, DESGREZ (1954), DESGREZ et coll, (1954) and MULRY et coll.They have shown that occasionally an accumulation of radiogallium may be demonstrated in osseous tumours before it can be detected at roentgen examination.The method has been used in examinations for primary osseous tumours as well as skeletal metastases. DESGREZ et coll. claim to have shown that a tumour is sometimes more extensive than may be assumed from its roentgenographic appearance, an observation of importance in the radiotherapy

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