Parathyroid tissue is clearly a site for production of IGF-1, TGF-β1, and VEGF. IGF-1 receptor activity was higher in normal parathyroid tissue compared to hyperplastic and adenomatous tissue.

114ucinous microglandular adenocarcinoma (MGA) is an uncommon subtype of endometrial adenocarcinoma which can be confused with mucinous adenocarcinoma (MUC-AD) and microglandular hyperplasia of the cervix or mucinous proliferations of the endometrium. [1][2][3] This neoplasm can mimic microglandular hyperplasia (MGH) particularly, which is characterized by closely packed glands lined by cuboidal or columMicroglandular Adenocarcinoma of the Endometrium: Case Report A AB BS ST TR RA AC CT T We report a case of endometrial microglandular adenocarcinoma which can be confused with microglandular hyperplasia and mucinous adenocarcinoma of the cervix and mucinous proliferation of the endometrium. A 54-year-old postmenopausal woman presented with vaginal bleeding. Histologically, endometrial biopsy was characterized by closely packed microglandular and mucinous glandular areas, which is lined by cuboidal and columnar cells. There was a multitude of neutrophils in microglandular lumens and stroma. Immunohistochemically, focal positivity for vimentin, CEA, estrogen and progesterone receptors were seen. The histology was suspicious for malignancy that might be compatible with microglandular adenocarcinoma of the endometrium resembling microglandular hyperplasia of the cervix. In the final workout of the hysterectomy specimen, we determined a superficial microglandular adenocarcinoma with no myometrial invasion. Several tubal, eosinophilic syncytial and squamous metaplasia areas were present. Pathologists require sufficient clinical information, morphologic experience and immunohistochemical assistance to make the correct pathological diagnosis in such confounding neoplasms. A An na ah ht ta ar r K Ke el li im me el le er r: : Endometriyal tümörler; adenokarsinom; hiperplazi; metaplazi T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J G Gy yn ne ec co ol l O Ob bs st t 2 20 01 16 6; ;2 26 6( (2 2) ): :1 11 14 4--8 8

ertoli-Leydig hücreli tümörler (SLHT), tüm over tümörlerinin %0,5'inden azını oluşturan, çoğunlukla (%90) tek overe lokalize, overin seks kord stromal tümörlerindendir.

Amaç: Serum Lipokalin 2 (LCN2) seviyelerinin psoriasiste artmış inflamasyon için bir genel belirteç olduğu bilinmektedir. Bu çalışmada, LCN2'nin psoriatik lezyonlardaki reseptör düzeyini araştırmayı amaçladık. Yöntemler: LCN2 immünohistokimyasal ekspresyonu, 31 psoriasis hastası ve 31 kontrol grubuna ait deri biyopsi örneklerinde araştırılmış ve sonuçlar guruplar arasında karşılaştırılmıştır. Bulgular: Hasta grubunda 19 (%61,3) plak psoriasisli hasta vardı ve bunların tamamında orta ve kuvvetli boyanma şiddetinde üst epidermal tabakada LCN2 immünohistokimyasal ekspresyonu saptanmıştır. Geriye kalan 12 hastada (%38,7) patolojik bulgulara göre, erken evre psoriatik lezyonları olan ve kontrol grubu biyopsilerinde epidermal LCN2 immünohistokimyasal ekspresyonu görülmemiştir. Kıl folliküllerinin iç kök kılıfında, LCN2 immünohistokimyasal ekspresyonu her iki gurupta da görüldü ve ekspresyonlar arasında istatistiksel anlamlı fark bulunamamıştır (p=1,00). Sonuç: Çalışmamızda, plak psoriasisli hastalarda üst epidermiste orta ve kuvvetli boyanma şiddetinde LCN2 immünohistokimyasal ekspresyonu tespit edilmiştir. Fakat kontrol grubu deri biyopsilerinde LCN2 immünohistokimyasal ekspresyonu epidermisde görülmemiştir. Bu bulgular, LCN2'nin psoriasis patogenezindeki önemine işaret edebilir. Öte yandan erken evre psoriatik lezyonları olan hastalarda ekspresyon saptanmaması LCN2'nin psoriasis patogenezinin ileri dönemlerinde etkin olduğunu düşündürmektedir. Objective: Serum Lipocalin 2 (LCN2) levels are a general indicator for increased inflammation in the patients with psoriasis. In this study, we aimed to investigate the receptor levels of LCN2 in psoriatic lesions. Methods: Immunohistochemical expression of LCN2 was investigated in 31 skin biopsy samples of patients with psoriasis and 31 skin biopsies of control group and the results were compared between the groups. Results: Among patient group, 19 patients (61.3%) had plaque psoriasis and in all of these, medium to strong staining intensity of LCN2 immunohistochemical expression was detected in the upper epidermal layer. In remaining 12 patients (38.7%) with pathologically early stage psoriatic lesions and control group epidermal LCN2 immunohistochemical expression was not observed. LCN2 immunohistochemical expression was detected in the inner root sheath of the hair follicles in both groups without any statistically difference (p=1.00). Conclusion:In our study, medium to strong staining of LCN2 receptor was detected in the superficial epidermis of the psoriatic plaques. But LCN2 immunohistochemical staining was not observed in control skin biopsies. These findings may point out the significance of LCN2 in pathogenesis of psoriasis. On the other hand, absence of expression in patients with early psoriatic lesions imply that LCN2 may be active at the later stages of the pathology.