Background. The Travelers Outpatient Clinic (DMIP/HC /FMUSP) was established in São Paulo in February 2001. Currently, patients attend the clinic for pre-travel consultation and in case of illness when return to the city. Post-travel evaluation is not done routinely. This research aims to expand the information about the trips; profile occurrences; assess pre-trip orientations; adherence and adequacy, impact on disease prevention, and may be used to improve the pre-travel orientation and quality of care. Methods. In the period from 03/02/2011 to 31/12/2011 were invited to participate in the study travelers seeking outpatient care for pre-travel consultation. Travelers who agreed to participate signed the informed consent form. The study was conducted in two stages. Pre-travel orientation: collecting data on general prevention measures recommended in relation to vector-borne diseases, food and water, accidental exposure to animals, and individual data on the conditions of travel, prior vaccination and health. Post-travel evaluation: A questionnaire was sent to participants 15 days after the expected travel return date. The responses were stored in Excel database. Descriptive statistics were used to present all relevant variables using Epi Info (CDC) and SPSS. Multivariate logistic regression was used to detect independent risk factors associated with the development of diarrhea. Results. Were obtained 150 responses (52.81% response rate); 94% of participants were Brazilians, (89%) had college education, 54.5% of the participants were between 25 and 44 years and 55.1% were female. The time from consultation until the trip was less than 28 days in 60.1%. Travel destination: Africa in 58 travelers (38.7%), followed by Asia in 43 (28.7%). Demand for medical services: 10.9% during the trip, and 6% in return. Cause of seeking medical care: diarrhea (31.2 %) followed by accidents in 18.7% and suspected malaria in 12.5%. Among the patients with diarrhea the accommodation in native houses (RR=2.38 P = 0.004) and multiple accommodations (RR=2.006 P = 0.020) were risk factors. Travel to Asia was also a risk (RR 1.93 P = 0.024). In multivariate analysis the association was not maintained. Regarding adherence to prophylactic measures recommended; the use of mineral water was high among all travelers (94.1%); use of hypochlorite, boiled water and cleaning food before consumption were higher in the group of travelers with diarrhea; finding hypochlorite for water consumption as a risk factor (P = 0.003) regardless of the country visited. Adherence to chemoprophylaxis for malaria was low, however only 9.6% of travelers at risk had malaria. Reporting of accidental exposure to other animals occurred in 4.7% of our travelers. The sexual relationship with acquaintances during the trip was