Flu encephalopathy is a rare and poorly understood complication of the influenza virus. In children, it presents most commonly in the 6-18 months age range and most often in the first 26 hours of flu symptoms. Here, we present a case of a 13-year old black female who presented with acute-onset encephalopathy two weeks into flu symptoms. As we begin this flu season, this case serves as a reminder that flu encephalopathy should be on the differential for acute-onset altered mental status.