The objective of this chapter is to provide a comprehensive end-to-end overview of existing communication subsystems residing on both the satellite bus and payloads. These subsystems include command and mission data handling, telemetry and tracking, and the antenna payloads for both command, telemetry and mission data. The function of each subsystem and the relationships to the others will be described in detail. In addition, the recent application of software defined radio (SDR) to advanced satellite communication system design will be looked at with applications to satellite development, and the impacts on how SDR will affect future satellite missions are briefly discussed.