A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.
The crystal structure of KLiO was determined by X-ray diffraction techniques. The compound crystallizes orthorhombically in the space group = Cmca (Z = 8) with the cell parameters a -861.8(4), b -640.3(2), c = 641.7(2) pm. The structure was solved from 1307 counter reflections (414 symmetry independent reflections) by direct methods and refined to a weighted least-squares residue of 0.05.The structure is characterized by condensed LiO"-anions in which Lithium is surrounded by three oxygen atoms.
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