This retrospective analysis demonstrated that more severe LA LGE is associated with increased MACCE risk, driven primarily by increased risk of stroke or TIA.

The REFINE SPECT registry will provide a resource for collaborative projects related to the latest generation SPECT-MPI. It will aid in the development of new artificial intelligence tools for automated diagnosis and prediction of prognostic outcomes.

The geometric confinement of TAV by the failed bioprosthesis or the calcified native valve increases the BRT on the TAV leaflets. This may act as a permissive factor in valve thrombosis.

OBJECTIVES-We aimed to study the ability of automated myocardial perfusion imaging analysis in comparison to visual analysis in major adverse cardiac events (MACE) prediction. BACKGROUND-Quantitative analysis has not been compared to clinical visual analysis in prognostic studies. METHODS-From the multi-center REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT), 19,495 patients (64±12 years, 56% male) undergoing stress Tc-99m SPECT-MPI were followed for 4.5±1.7 years for MACE. Perfusion abnormalities were assessed visually and categorized as normal, probably normal, equivocal, and abnormal. Stress total perfusion deficit (TPD), quantified automatically was categorized as TPD=0%,