No abstract

Scorpion venom is an antigenic, water-soluble, heterogenous mixture. The Na + -channel specific toxins from scorpions are modifiers of the channel gating mechanism. The recombinant DNA vaccines involved targeting multiple antigenic components to direct and empower the immune system to protect the host from infection. Limitation of therapy to the treatment of patients suffering from various adverse reaction and contraindications are always experienced. Antigenic epitope on iberiotoxineastern Indian scorpion are important determinant of protection against spider venom. As our knowledge of the immune responses to a protein antigen progressed, it became clear that the whole protein is not necessary for raising the immune response, but small segments (DVDCSVSKECWSVCKDLFG; 4-22) of protein called the antigenic determinant or the epitope is sufficient for eliciting the desired immune response. In analysis predicted antigenic epitope iberiotoxin protein is seen. Antigenic epitope from iberiotoxin is a predicted immunization strategy against various diseases.

Abstract-Foot-and-mouth disease is caused by FMDV, an Aphthovirus of the viral family Picornaviridae. Peptide fragments of Foot-and-mouth disease virus protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of protein from Footand-mouth disease virus are important determinant for protection of host form viral infection. In this assay we predicted the binding affinity of protein having 213 amino acids, which shows nonamers. These peptides are from a set of aligned peptides known to bind to a given MHC molecule as the predictor of MHC-peptide binding. MHCII molecules bind peptides in similar yet different modes and alignments of MHCII-ligands were obtained to be consistent with the binding mode of the peptides to their MHC class, this means the increase in affinity of MHC binding peptides may result in enhancement of immunogenicity of protein nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Foot-and-mouth disease virus.