Prostaglandins (PG) and their specific receptors for E type PG (EP) play an important role in inflammatory diseases. Although myocarditis results in inflammation of the heart, roles of PG and EP in its pathophysiology is still controversial. To clarify the role of PG and EP on the progression of myocarditis, we used an experimental autoimmune myocarditis model. A selective EP4 (EP4RAG) agonist was administered into both early (Day 0 to 21) and late (Day 14 to 21) -treated groups and the animals were killed on Day 21. We found that improved cardiac function was detected in the EP4RAG-treated groups in comparison to the untreated group. The infiltration area ratio in the early-treated (16.6% ± 4.6%) group was lower than those in the untreated group (32.1% ± 3.5%) (P < 0.05). The fibrosis area ratios in the early-treated (19.2% ± 6.3%) and the late-treated groups (24.4% ± 5.1%) were lower than those in the untreated group (37.4% ± 2.6%), respectively (P < 0.05). Moreover, we found that EP4RAG decreased T-cell proliferation and monocyte chemoattractant protein-1 production in vitro. We concluded that a selective EP4 agonist inactivates T-cells, which turns out to moderate the progression of experimental autoimmune myocarditis. Therefore, EP4 can be an effective target for myocarditis treatment.

-This paper introduces the petrographic characteristics and depositional environment of Middle Miocene rocks of the Thien Ung -Mang Cau structure in the central area of Nam Con Son Basin based on the results of analyzing thin sections and structural characteristics of core samples. Middle Miocene sedimentary rocks in the studied area can be divided into three groups: (1) Group of terrigenous rocks comprising greywacke sandstone, arkosic sandstone, lithic-quartz sandstone, greywacke-lithic sandstone, oligomictic siltstone, and bitumenous claystone; (2) Group of carbonate rocks comprising dolomitic limestone and bituminous limestone; (3) Mixed group comprising calcareous sandstone, calcarinate sandstone, arenaceous limestone, calcareous claystone, calcareous silty claystone, dolomitic limestone containing silt, and bitumen. The depositional environment is expressed through petrographic characteristics and structure of the sedimentary rocks in core samples. The greywacke and arkosic sandstones are of medium grain size, poor sorting and roundness, and siliceous cement characterizing the alluvial and estuarine fan environment expressed by massive structure of core samples. The mixed calcareous limestone, arenaceous dolomitic limestone, and calcareous and bituminous clayey siltstone in the core samples are of turbulent flow structure characterizing shallow bay environment with the action of bottom currents. The dolomitic limestones are of relatively homogeneous, of microgranular and fine-granular texture, precipitated in a weakly reducing, semi-closed, and relatively calm bay environment.

The seismic properties of Root Mean Square Amplitude, Maximum Amplitude, and Sum of Positive Amplitude most clearly reflect the distribution characteristics of middle Miocene carbonate sediments in ​​block 04-3, Nam Con Son basin. Middle Miocene carbonate is commonly distributed on both reflection surfaces of  P1 and P2. Within each reflective surface, carbonate sediments are concentrated around the uplifting zones, such as structures of Thien Ung - Mang Cau, Dai Hung and Bo Cau. These are completely consistent with the results of the interpretation of well-log data of Vietsovpetro, VSP [1]. The wells C-2X and C-4X  located at the edge of the uplifting zone should have the thickest carbonates. According to the results of amplitude attribute analysis, these wells are distributed in the high concentration area of carbonate formations. Meanwhile well C-1X  and well C-3X, which are near the top of the uplifting zone and further away from the uplifting structure have thin carbonate set and belongs to a low carbonate density area.

No abstract

No abstract